MAXIMUM SAFE DOSE, 1000 mg Dangerous ground to tread on.  This sense of unity tends to define the San Pedro experience—unity with oneself, with other people and the natural world, and with all of existence at large. In fact, one of the traditional therapeutic uses for peyote was as an antidepressant, and depression scores are reportedly low among members of the Native American Church, where peyote use is common..
Tolerance to mescaline builds up almost immediately and takes roughly 7 days of abstinence to return to baseline.
 In fact, it tends to have the opposite effect of actually sharpening the senses and enhancing mental clarity. 2.0 - 2.5 inch diameter section = 1.5 ounces per inch of length. San Pedro is best taken on an empty stomach as a brew, juice, or dried powder (i.e. San Pedro, The Miracle Healer. It also specifically decriminalizes (or rather deprioritizes for law enforcement) their cultivation and distribution.  Kovacic, P., Somanathan, R. (2009). San Pedro curanderismo (folk healing) ceremonies were held on June 24th, the Nativity of Saint John the Baptist, for example, while the name of the plant itself—San Pedro, Spanish for Saint Peter—is thought to imply that, like the Christian saint, the cactus “holds the keys to heaven.”, But this foreign context was superimposed onto existing, pre-Hispanic/pre-Columbian ideas.  It’s best to work with a qualified San Pedro ceremony facilitator to ensure you get the right dose.
, San Pedro may not be safe in combination with MAOIs (natural or synthetic), including the antidepressants phenelzine (Nardil) and tranylcypromine (Parnate). Although it was found to contain less of the psychedelic compound than peyote (<2% by dry weight and 0.12% fresh), San Pedro still represented a significant alternative source.  Just be aware—if you’re growing San Pedro for mescaline, the common horticultural form of T. pachanoi (aka “pachanot”) has little to none of the compound. If you are new to microdosing or to psychoactive plants, it is wise to start at the lowest level of recommended dosage and work your way up. Eleusis, 5:13-59. San Pedro Dosage Discussion. Retrieved from https://erowid.org/plants/cacti/cacti_guide/cacti_guide_trichoce.shtml. When ingesting fresh cactus, 10–20 grams is recommended for a hallucinatory dose. The Psychedelic Guide to the Preparation of the Eucharist.
Mescaline is the sought-after psychoactive alkaloid in San Pedro, making up only about 0.1% of the substance when ingesting in raw cactus form.
In modern times, self-experimenters around the world are reporting a much wider range of benefits, including personal insights, mood enhancement, increased empathy and creativity, lifestyle changes, and even lucid dreams. Mescaline is a different chemical class from other commonly microdosed psychedelic substances like LSD (an ergoline) and psilocybin (a tryptamine).  Virtually all labs require a specific test for the substance, so unless your employer is a real stickler and specifically suspects San Pedro use, you should be fine. When ingesting fresh cactus, 10–20 grams is recommended for a hallucinatory dose.
It’s interesting to note that while alcohol abuse rates among the Navajo and other Native American tribes are said to be roughly twice the U.S. average, they are significantly lower among NAC members.
In the Embrace of Pachamama: An Experience with Cacti – T. pachanoi (exp50479). At The Third Wave, our mission is to share trusted, research-based content that helps you feel safe, supported, and empowered as you follow your path towards personal transformation.
 “Out-of-body” experiences are also common, as is synesthesia (e.g.  At the same time, ordinary things around you can appear more interesting, beautiful, and amazingly mystical—qualities that define the mescaline experience. PEYOTE: Uses, Side Effects, Interactions and Warnings – WebMD. Mescaline also affects the dopamine receptors in our brain. in capsules or stirred into water). A 2008 study concluded that mescaline had “extraordinarily potent” anti-inflammatory effects, and a 2018 study found that psychedelics in general help regulate inflammatory pathways, which could prove therapeutic for a number of diseases, including asthma, atherosclerosis, inflammatory bowel disease, and retinal disease.
This is a time for reflection, as well as providing time for the body to start producing new neurotransmitters in the brain. Psychoactive Painted Peruvian Plants: The Shamanism Textile.
San Pedro has long been considered a powerful agent for healing and change, making it a central component of the shamanic ceremonies of many indigenous groups in the Americas. MODERATE DOSE, 200 - 300 mg Average dosage, strong visuals.
Chasing it down with fruit juice (especially unsweetened grapefruit juice) may help, but folk wisdom holds that “if one’s heart is pure, the bitterness will not be tasted.” In other words, if you’re mindful of the bitterness, experiencing it without resistance, the gag reflex shouldn’t kick in. During the month-long break without the medicine, an individual has time to reflect on the experiences and personal growth. Journal of Ethnopharmacology, 131(2):356-362.
 Controlled Drugs and Substances Act (S. C. 1996, c. 19). This way you can develop connections and allow your energy vibration to rise and also allow your psychological aspect to have more clarity and introspection, an overall awareness.”, When microdosing San Pedro it is important to know the source of your product.
San Pedro Potency FAQ. Some do point out that the wisdom of the cultures of the Amazon basin will only be spread to all of humanity by bringing in outsiders. For safety and ethical reasons, it’s best to experience San Pedro in the context of a ceremony with a qualified curandero (healer), which are becoming more common in the West, in addition to the growing number of retreats in South America.
(2016, Sep 15).
Like Raimutsa, some may choose to dose twice a day, once with breakfast and again at lunch if they are planning a late night of work. To help you figure out how much weight you have for a given size section, here are some figures.
(1999). The neurotransmitters that mescaline activates affect how we feel, and how we process information. She has been curiously experimenting with a wide range of psychedelics since the ripe age of 14 years of age.  Sharon, D. (2001). The threshold dosage for mescaline is generally considered to be around 150 mg. An " average" working dose is around 300 mg. A 400 mg. dose has been described as an " entheogenic all day lollipop ." , Before ingesting San Pedro, ceremony participants are “purified” with a bath of “spiritual flowering” or baño de florecimiento, and often snort tobacco. Resolution.  In Canada, where peyote (and only peyote) is specifically exempt from the mescaline ban, prosecutors may need to show even stronger evidence of intent than elsewhere. Analyses of T. peruvianus have found mescaline concentrations of up to 0.817% (dried whole plant), with some finding none at all. Retrieved from https://erowid.org/experiences/exp.php?ID=50479.
), San Pedro is generally legal, even as a psychedelic.. In fact, mescaline, like other psychedelics, is well known for enhancing creativity.  steppingintofreedom.  People with colon problems, high blood pressure, heart conditions, diabetes, or mental illness should also be cautious.
However, as “psychedelic tourism” becomes a growing industry in South America, there is also concern over unsustainable harvesting practices. (1973). I see my dad chilled out and feeling healthy. These breaks are important for your body, and to give yourself time to observe the effects of the medicine. The Ultimate Guide To Psilocybin Mushrooms, reduced rates of alcoholism and drug abuse, https://erowid.org/plants/cacti/cacti_info1.shtml, https://erowid.org/experiences/exp.php?ID=26305, https://erowid.org/experiences/exp.php?ID=109945, https://erowid.org/experiences/exp.php?ID=37131, https://erowid.org/experiences/exp.php?ID=42192, https://erowid.org/experiences/exp.php?ID=100145, https://erowid.org/experiences/exp.php?ID=78714, https://psychonautwiki.org/wiki/Mescaline, https://erowid.org/plants/cacti/cacti_culture1.shtml, https://erowid.org/plants/cacti/cacti_writings1.shtml, https://erowid.org/plants/cacti/cacti_sanpedro_potency_faq.shtml, https://erowid.org/plants/cacti/cacti_dose1.shtml, https://erowid.org/plants/cacti/cacti_guide/cacti_guide_trichoce.shtml, https://www.erowid.org/ask/ask.php?ID=2942, http://www.steppingintofreedom.com/huachuma-and-prescribed-medication, http://nativemothering.com/2011/05/should-i-use-peyote-if-i-am-pregnant-or-breastfeeding/, http://www.healthprioritiesinc.com/ns/DisplayMonograph.asp?StoreID=c8ad0990cf0d44a5bac9118cf4159a55&DocID=bottomline-peyote, https://www.erowid.org/ask/ask.php?ID=3089, http://discovermagazine.com/2009/the-brain/peyote, https://psmag.com/news/whats-behind-the-myth-of-native-american-alcoholism, https://erowid.org/experiences/exp.php?ID=96587, https://erowid.org/plants/cacti/cacti_article1.shtml, http://volteface.me/features/the-diverging-mind/, http://www.psychedelic-library.org/artist.htm, https://erowid.org/experiences/exp.php?ID=40970, https://erowid.org/experiences/exp.php?ID=50479, https://erowid.org/experiences/exp.php?ID=56932, https://erowid.org/plants/cacti/cacti_law.shtml, https://www.apnews.com/ff023dfbf4534eba8622f504d272ff00, https://www.decriminalizenature.org/dno-resolution, http://laws.justice.gc.ca/eng/acts/C-38.8/page-14.html#docCont, http://www.druglawreform.info/en/country-information, https://mycotopia.net/topic/51844-the-history-of-mescaline-by-klaus-trenary/, http://ens-newswire.com/2017/04/06/insights-mining-perus-andean-forests-puts-unique-species-ecosystem-at-risk/, https://erowid.org/chemicals/mescaline/mescaline_testing.shtml, https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=52630, https://www.webmd.com/vitamins-supplements/ingredientmono-473-peyote.aspx?activeingredientid=473&activeingredientname=peyote. Retrieved from https://erowid.org/ask/ask.php?ID=1778. That said, we can’t offer medical advice and we don’t encourage illegal activities. Biological Psychiatry, 58(8):624-31. doi:10.1016/j.biopsych.2005.06.038.  Stafford, P. (1992). Microdosing powder is recommended at a dosage of from 3–10 mg, which is usually anywhere from 0.25–3 grams of dry cactus powder. Get the best of the psychedelic renaissance delivered to your inbox!
Like Saints Peter and John, San Pedro had long been associated with water, albeit more specifically with the fertility of Pachamama (the ‘earth mother’) and mystical “flows between worlds.” Hence the Ecuadorian name, aguacolla, is thought to have originated with the Spanish word agua (water) and Quechua word colla (queen), or else with another Quechua term denoting something hidden or occult—“hidden water,” in other words, or a portal to “another world.”, Out-of-body journeys are a hallmark of San Pedro’s traditional use. Beverly, MA: Fair Winds Press. Raimutsa recommends 1–2 droppers in the morning with breakfast.
 Heaven, R. (2009).
See our Essential Guide to Microdosing Mescaline.
Retrieved from https://erowid.org/plants/cacti/cacti_culture1.shtml. Keep in mind that fresh cactus is not the same as dry, cured cactus powder.
XIX. In its original use, the plant medicine was also used to treat a number of ailments, including snake bites, wounds, skin conditions, and general pain. War Amongst the Clouds: An Experience with Cacti – San Pedro (exp100145).
Using data from the National Survey on Drug Use and Health, the researchers found that people who have used a psychedelic drug at least once in their life show lower rates of suicidal thinking. These ceremonies often last all night and are repeated over several days. Stay up to date on the third wave of psychedelics with our weekly newsletter, insider conversations, research highlights, special microdosing discounts, and much more. Cactus Alkaloids.
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